In what circumstance should a nurse withhold a nephrotoxic medication?

Withholding a nephrotoxic medication is most appropriate when the patient's creatinine level is significantly elevated. Elevated creatinine levels indicate impaired kidney function, which can lead to decreased clearance of medications and increased risk of toxicity. Nephrotoxic medications can further exacerbate these issues, leading to potential acute kidney injury. Therefore, in the presence of elevated creatinine, continuing nephrotoxic therapy could be harmful to the patient and should be reassessed.

In contrast, low blood pressure, dizziness, or fever could suggest a need for further assessment or intervention, but they do not directly indicate the compromised functionality of the kidneys in the same way that elevated creatinine does. While these conditions may warrant clinical attention, they do not specifically necessitate withholding a nephrotoxic medication unless they are accompanied by signs of renal impairment.