What symptom should a patient on trimethoprim-sulfamethoxazole report to the nurse?

A patient on trimethoprim-sulfamethoxazole should be aware of the potential for developing significant side effects, and a sore throat is particularly noteworthy. This symptom can indicate the onset of a serious adverse reaction, such as agranulocytosis or other hematologic abnormalities, which are associated with this medication.

Monitoring for signs of infection or changes in the immune system is crucial due to the potential impact on white blood cell counts. A sore throat may signal the need for immediate evaluation, as it could suggest a drop in neutrophil levels or the development of a secondary infection.

While skin rash, headache, and high fever are important symptoms to monitor as well, they may not be as directly indicative of an urgent hematological concern compared to a sore throat, which necessitates prompt assessment and possible intervention.