Which medication class can lead to acute tubular necrosis if not properly dosed in renal patients?

Aminoglycoside antibiotics are known to cause acute tubular necrosis, particularly in patients with existing renal impairment or those receiving high doses without proper renal dosing adjustments. These medications can be nephrotoxic, as they accumulate in the renal tubules, leading to cellular damage and dysfunction.

When aminoglycosides are not appropriately dosed, especially in patients with compromised kidney function, the risk of toxicity increases. The renal clearance of these drugs is significantly reduced in such patients, which can result in increased systemic concentrations and a heightened likelihood of adverse effects, including acute tubular necrosis.

It’s important for healthcare providers to monitor renal function closely in patients receiving aminoglycosides, ensuring that the dosage is tailored to the patient’s renal capabilities. This careful adjustment helps mitigate the risk of nephrotoxicity and helps to preserve kidney function while effectively treating the underlying condition.